Definition of Venetoclax. Meaning of Venetoclax. Synonyms of Venetoclax

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Definition of Venetoclax

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Meaning of Venetoclax from wikipedia

- Venetoclax, sold under the brand names Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic leukemia (CLL), small lymphocytic...
- selective inhibitor venetoclax (ABT-199), which inhibits Bcl-2, but not Bcl-xL or Bcl-w. Clinical trials studied the effects of venetoclax, a BH3-mimetic drug...
- (BCL-2) inhibitor, venetoclax, plus a CD20 antibody obinutuzumab, OR BTKi (i.e. ibrutinib) plus BCL-2 inhibitor (i.e. venetoclax) CLL is the most common...
- juvenile myelomonocytic leukemia. The combination of azacitidine and venetoclax is also approved for AML. Azacitidine is a chemical analogue of the nucleoside...
- variant, which limits the effectiveness of first-generation inhibitors like venetoclax. "Sonrotoclax - BeiGene". AdisInsight. Springer Nature Switzerland AG...
- to be one of the most up-regulated (i.e. overactive) genes in BPDCN. Venetoclax inhibits the apoptosis-inhibiting action of BCL-2 and proved active in...
- sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax". Haematologica. 108 (10): 2837–2843. doi:10.3324/haematol.2022.282160...
- (i.e. DH/THL). RO6870810, another BET inhibitor, in combination with Venetoclax, an inhibitor of the Bcl-2 protein, is likewise in a phase I clinical...
- about 15-20% of multiple myeloma patients) may particularly benefit from Venetoclax therapy (which is FDA approved for other blood cancers but not yet available...
- SY, Arrate MP, Chang H, Gorska AE, Fuller LD, et al. (February 2020). "Venetoclax response is enhanced by selective inhibitor of nuclear export compounds...