-
stimulated by
VEGF: sunitinib, sorafenib, axitinib, and
pazopanib (some of
these therapies target VEGF receptors rather than the
VEGFs). Both antibody-based...
-
biomarkers for
bevacizumab efficacy are not yet known.
Current studies show that
VEGFs are not the only
promoters of angiogenesis. In particular, FGF2 and HGF...
-
VEGF receptors (VEGFRs) are
receptors for
vascular endothelial growth factor (
VEGF).
There are
three main
subtypes of VEGFR,
numbered 1, 2 and 3. Depending...
-
Vascular endothelial growth factor A (
VEGF-A) is a
protein that in
humans is
encoded by the
VEGFA gene. This gene is a
member of the platelet-derived growth...
-
structures upon
stimulation by
VEGF and bFGF,
although the
results were more
pronounced with
VEGF.
Upregulation of
VEGF is a
major component of the physiological...
- and are
collectively referred to as PVFs (PDGF/
VEGF-like
growth factors. The
comparison of
human VEGFs with
these PVFs
allows conclusions on the structure...
-
pegaptanib and aflibercept.
These anti-
VEGF agents may be
administered monthly or adaptively. For
adaptive anti-
VEGF treatment, two
approaches are conventionally...
-
circulating VEGFs and acts like a "
VEGF trap". It
thereby inhibits the
activity of the
vascular endothelial growth factor subtypes VEGF-A and
VEGF-B, as well...
- released. It is
almost certain that
vascular endothelial growth factor (
VEGF) is a key
substance that
induces vascular hyperpermeability,
making local...
- cells, and
megakaryocytes all
express VEGF; both IL1 and IL6 have been
proven to
increase VEGF synthesis.
VEGF normally targets endothelial cells and...
