- VEGF
receptors (
VEGFRs) are
receptors for
vascular endothelial growth factor (VEGF).
There are
three main
subtypes of
VEGFR,
numbered 1, 2 and 3. Depending...
-
kinases (
VEGFR-1,
VEGFR-2 and
VEGFR-3).
VEGFR-1, or FLT-1 (fms-like
tyrosine kinase), are
important for
hematopoietic stem cell development,
VEGFR-2 (KDRor...
- to
VEGFR-1 (Flt-1) and
VEGFR-2 (KDR/Flk-1).
VEGFR-2
appears to
mediate almost all of the
known cellular responses to VEGF. The
function of
VEGFR-1 is...
- to
VEGFR-1 (Flt-1) and
VEGFR-2 (KDR/Flk-1).
VEGFR-2
appears to
mediate almost all of the
known cellular responses to VEGF. The
function of
VEGFR-1 is...
- of
VEGFR-1 is
required for
normal development and angiogenesis.
VEGFR-1
inhibits the
activity of
VEGFR-2 by
sequestering VEGF, thus
preventing VEGFR-2...
-
growth factor receptor (
VEGFR) 1, 2, and 3; and FLT3. Its use in IPF is
predicated on its
inhibition of PDGFR, FGFR, and
VEGFR,
which increase fibroblast...
-
tyrosine kinase) also
known as
vascular endothelial growth factor receptor 2 (
VEGFR-2) is a VEGF receptor. KDR is the
human gene
encoding it. KDR has also been...
-
approved Tucatinib HER2
Seattle Genetics Small molecule 2020
Vandetanib RET/
VEGFR/EGFR
AstraZeneca Small molecule 2011
Vemurafenib BRAF
Roche Small molecule...
- appropriate, an anti-EGFR therapy. The
earlier generation small molecule VEGFR inhibitors, such as sunitinib,22 sorafenib,23 regorafenib24 and pazopanib25...
- the VEGF
pathway include antibodies directed against VEGF or
VEGFR,
soluble VEGFR/
VEGFR hybrids, and
tyrosine kinase inhibitors. The most
widely used...
