- The
enzyme urate oxidase (UO),
uricase or factor-independent
urate hydroxylase,
absent in humans,
catalyzes the
oxidation of uric acid to 5-hydroxyisourate:...
- with methotrexate.
Pegloticase is a
PEGylated recombinant porcine-like
uricase.
Similarly to rasburicase, it
metabolises uric acid to allantoin. This...
- (Affymax/Takeda Pharmaceuticals, 2012)
Pegloticase (Krystexxa) –
PEGylated uricase for the
treatment of gout (Savient, 2010)
Certolizumab pegol (Cimzia) –...
- Administration. June 2023.
Sherman MR,
Saifer MG, Perez-Ruiz F (January 2008). "PEG-
uricase in the
management of treatment-resistant gout and hyperuricemia". Advanced...
-
whereas in most
other mammals, the
enzyme uricase further oxidizes uric acid to allantoin. The loss of
uricase in
higher primates parallels the similar...
- is a
degradation product of
nucleic acids, by
action of
urate oxidase (
uricase).
Allantoin also
occurs as a
natural mineral compound (IMA
symbol Aan)...
- H; Preddie, E (February 1983). "Nodulin-35: A
subunit of
specific uricase (
uricase II)
induced and
localized in the
uninfected cells of
soybean nodules"...
-
produce uricase,
which breaks down uric acid.
Humans and
other great apes do not have this ability; thus, gout is common.
Other animals with
uricase include...
- and butyrate. In
mouse models, such
bacteria compensate for the loss of
uricase leading researchers to
raise the
possibility "that
antibiotics targeting...
- 20 to 16 Ma. They
largely reduced their ancestral snout and lost the
uricase enzyme (present in most organisms). 16-12 Ma
Homininae ancestors speciate...
