-
these types of
binding sites on
proteins are
generally thought to be
undruggable but
there has been some
progress (by 2009)
targeting these sites. Chemoproteomics...
-
molecule therapeutics and
therapeutic modalities against traditionally "
undruggable" proteins. He is a
member of the
scientific advisory committee of the...
-
reducing off-target effects.
PROTACs have the
ability to
target previously undruggable proteins, as they do not need to
target catalytic pockets. This also...
- However,
targeting cancer proteins can be difficult, as a
protein can be
undruggable. The war on
cancer began with the
National Cancer Act of 1971, a United...
- oncogene.
Investigators and
pathologists previously thought that K-Ras is
undruggable. However,
Kevan M.
Shokat and his colleagues, in the
Howard Hughes Medical...
-
Fesik SW,
Kimmelman AC, Luo J, Der CJ (November 2014). "Drugging the
undruggable RAS:
Mission possible?".
Nature Reviews. Drug Discovery. 13 (11): 828–851...
-
November 2019.
Kaiser J (October 2019). "Two new
drugs finally hit '
undruggable'
cancer target,
providing hope for treatments". Science. doi:10.1126/science...
- the work of
Koehler it was
understood that
transcription factors were "
undruggable", as
their inherent structural disorder compromised the
binding of small-molecule...
- pathways. They have
unlocked avenues in
medicine previously thought to be "
undruggable". The
concept of "molecular glue"
originated in the late 20th century...
- Dang CV,
Reddy EP,
Shokat KM,
Soucek L (August 2017). "Drugging the '
undruggable'
cancer targets".
Nature Reviews. Cancer. 17 (8): 502–508. doi:10.1038/nrc...
