-
these types of
binding sites on
proteins are
generally thought to be
undruggable but
there has been some
progress (by 2009)
targeting these sites. Chemoproteomics...
- However,
targeting cancer proteins can be difficult, as a
protein can be
undruggable. The war on
cancer began with the
National Cancer Act of 1971, a United...
-
Fesik SW,
Kimmelman AC, Luo J, Der CJ (November 2014). "Drugging the
undruggable RAS:
Mission possible?".
Nature Reviews. Drug Discovery. 13 (11): 828–851...
-
glues have
shown promise in
targeting proteins previously considered "
undruggable" by
conventional methods. They work
through various mechanisms, such...
-
reducing off-target effects.
PROTACs have the
ability to
target previously undruggable proteins, as they do not need to
target catalytic pockets. This also...
- cell-penetrating
ability of
small molecules.
Verdine coined the term "drugging the
undruggable" to
describe the
unique capabilities of
stapled peptides. A
close analog...
-
availability of
binders to
pharmacologically important, but so-far “
undruggable”
target proteins opens new
possibilities to
develop novel drugs for diseases...
-
molecule therapeutics and
therapeutic modalities against traditionally "
undruggable" proteins. He is a
member of the
scientific advisory committee of the...
- oncogene.
Investigators and
pathologists previously thought that K-Ras is
undruggable. However,
Kevan M.
Shokat and his colleagues, in the
Howard Hughes Medical...
- Dang CV,
Reddy EP,
Shokat KM,
Soucek L (August 2017). "Drugging the '
undruggable'
cancer targets".
Nature Reviews. Cancer. 17 (8): 502–508. doi:10.1038/nrc...
