-
ubiquitin to a
substrate protein is
called ubiquitylation (or
ubiquitination or ubiquitinylation).
Ubiquitylation affects proteins in many ways: it can mark...
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ubiquitination to
specific substrate proteins.[citation needed] The
ubiquitylation reaction proceeds in
three or four
steps depending on the mechanism...
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hydroxylates the
proline at the 564
position of HIF-1 alpha,
which allows ubiquitylation by the von Hippel-Lindau
tumor suppressor (pVHL) and
subsequent targeting...
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recruitment and
summoning of the IKK (IkB kinase), TAK1, by
several ubiquitylation enzymes also ****ociated with the CARMA1/BCL10/MALT1 complex. MALT1 itself...
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ubiquitin and
subsequent ubiquitin binding to E1.
Schematic diagram of the
ubiquitylation system. The
following genes encode ubiquitin-activating enzymes: UBA1...
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glycosylation 2844
Amidation 1619
Hydroxylation 1523
Methylation 1133 O-linked
glycosylation 878
Ubiquitylation 826
Pyrrolidone carboxylic acid 504 Sulfation...
- cis-imidazoline
analog nutlin.
Levels and
stability of Mdm2 are also
modulated by
ubiquitylation. Mdm2 auto
ubiquitylates itself,
which allows for its
degradation by...
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highly modified.
These modifications include acetylation, methylation,
ubiquitylation, phosphorylation, sumoylation,
ribosylation and citrullination. Acetylation...
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targeting Signal peptide Mitochondrial targeting signal Ubiquitin (
ubiquitylation) E1 Ubiquitin-activating
enzyme UBA1 UBA2 UBA3 UBA5 UBA6 UBA7 ATG7 NAE1...
- of
ubiquitylation and
pupylation is different,
owing to
their distinct evolutionary origins. In
contrast to the three-step
reaction of
ubiquitylation, pupylation...