-
Although the
majority of
protein substrates are
ubiquitylated,
there are
examples of non-
ubiquitylated proteins targeted to the proteasome. The polyubiquitin...
-
complex marks an
inhibitory chaperone called securin for
destruction by
ubiquitylating it.
Securin is a
protein which inhibits a
protease known as separase...
- HIF when
oxygen is
present at
acceptable levels; the VHL
protein then
ubiquitylates the HIF
protein which ultimately leads to the HIF protein's destruction...
-
other ubiquitin-conjugating enzymes. This
protein is
found to bind and
ubiquitylate synphilin 1 (SNCAIP),
which is an
interacting protein of alpha-synuclein...
-
Faustrup H,
Melander F,
Bartek J,
Lukas C, et al. (November 2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
proteasome regulates protein expression and
function by
degradation of
ubiquitylated proteins, and also rids the cell of
abnormal or
misfolded proteins....
- The
ubiquitin ligases RNF8 and RNF168 bind to the γH2AX/MDC1 complex,
ubiquitylating other chromatin components. This
allows the
recruitment of BRCA1 and...
- One
notable exception to this is p21 protein,
which appears to be
ubiquitylated using its N-terminal amine, thus
forming a
peptide bond with ubiquitin...
