-
complex marks an
inhibitory chaperone called securin for
destruction by
ubiquitylating it.
Securin is a
protein which inhibits a
protease known as separase...
-
Although the
majority of
protein substrates are
ubiquitylated,
there are
examples of non-
ubiquitylated proteins targeted to the proteasome. The polyubiquitin...
- One
notable exception to this is p21 protein,
which appears to be
ubiquitylated using its N-terminal amine, thus
forming a
peptide bond with ubiquitin...
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
Faustrup H,
Melander F,
Bartek J,
Lukas C, et al. (November 2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
- more
dependent on the KEN box. For example, APC/CCdh1 is
capable of
ubiquitylating KEN box-only-containing
substrates like Tome-1 and Sororin. Although...
-
proteasome regulates protein expression and
function by
degradation of
ubiquitylated proteins, and also rids the cell of
abnormal or
misfolded proteins....
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
through non-degradative
ubiquitylation of CDC20. Conversely, the de-
ubiquitylating enzyme protectin is
required to
maintain the SAC. Thus,
unattached kinetoc****s...
- The
ubiquitin ligases RNF8 and RNF168 bind to the γH2AX/MDC1 complex,
ubiquitylating other chromatin components. This
allows the
recruitment of BRCA1 and...
