-
Although the
majority of
protein substrates are
ubiquitylated,
there are
examples of non-
ubiquitylated proteins targeted to the proteasome. The polyubiquitin...
-
regulate cytosolic protein localization. For example, the E3
ligase MDM2
ubiquitylates p53
either for
degradation (K48
polyubiquitin chain), or for nuclear...
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
complex marks an
inhibitory chaperone called securin for
destruction by
ubiquitylating it.
Securin is a
protein which inhibits a
protease known as separase...
-
Faustrup H,
Melander F,
Bartek J,
Lukas C, et al. (November 2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
- HIF when
oxygen is
present at
acceptable levels; the VHL
protein then
ubiquitylates the HIF
protein which ultimately leads to the HIF protein's destruction...
- S,
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
Faustrup H,
Melander F,
Bartek J,
Lukas C,
Lukas J (November 2007). "RNF8
ubiquitylates histones at DNA double-strand
breaks and
promotes ****embly of repair...
-
proteasome regulates protein expression and
function by
degradation of
ubiquitylated proteins, and also rids the cell of
abnormal or
misfolded proteins....
-
protein 19". Niwa J,
Ishigaki S,
Hishikawa N, et al. (2002). "Dorfin
ubiquitylates mutant SOD1 and
prevents mutant SOD1-mediated neurotoxicity". J. Biol...
