-
addition of
ubiquitin to a
substrate protein is
called ubiquitylation (or
ubiquitination or ubiquitinylation).
Ubiquitylation affects proteins in many ways:...
-
pathway which targets misfolded proteins of the
endoplasmic reticulum for
ubiquitination and
subsequent degradation by a protein-degrading complex,
called the...
- degradation.
Recruitment of the E3
ligase to the
target protein results in
ubiquitination and
subsequent degradation of the
target protein via the proteasome...
- the
agonists for
ligands and R-SMADs, the
decoy receptors, and the
ubiquitination of R-SMADs and receptors. Both
chordin and
noggin are
antagonists of...
-
lysine residues in p53 C-terminus have been
identified as the
sites of
ubiquitination, and it has been
shown that p53
protein levels are
downregulated by...
-
possible and
alter a protein's activity, interactions, or localization.
Ubiquitination by E3
ligases regulates diverse areas such as cell trafficking, DNA...
- complex) is a multi-protein E3
ubiquitin ligase complex that
catalyzes the
ubiquitination of
proteins destined for 26S
proteasomal degradation.
Along with the...
-
their translation and
typically involves changes in
phosphorylation and
ubiquitination,
although nitrosylation,
deamidation and
hydroxylation have also been...
-
removal from the
protein leads to less
ubiquitination or if
their addition to
another protein leads to more
ubiquitination. In contrast, ubiquitin-independent...
-
protein that in
humans is
encoded by the FBXO40 gene. Fbxo40
induces ubiquitination of IRS1, thus
limiting activity of IGF1
signaling (Shi et al, 2011)...
