-
addition of
ubiquitin to a
substrate protein is
called ubiquitylation (or
ubiquitination or ubiquitinylation).
Ubiquitylation affects proteins in many ways:...
-
possible and
alter a protein's activity, interactions, or localization.
Ubiquitination by E3
ligases regulates diverse areas such as cell trafficking, DNA...
- degradation.
Recruitment of the E3
ligase to the
target protein results in
ubiquitination and
subsequent degradation of the
target protein via the proteasome...
- mice is
encoded by the PARK2 gene.
Parkin plays a
critical role in
ubiquitination – the
process whereby molecules are
covalently labelled with ubiquitin...
-
Through a
mechanism which has not been
completely elucidated, this
ubiquitination results in
reduced levels of
fibroblast growth factor 8 (FGF8) and fibroblast...
-
conformational change of the proteasome,
translocation dependent de-
ubiquitination by Rpn11,
followed by
unfolding and
proteolysis by the 20S core particle...
-
pathway which targets misfolded proteins of the
endoplasmic reticulum for
ubiquitination and
subsequent degradation by a protein-degrading complex,
called the...
-
lysine residues in p53 C-terminus have been
identified as the
sites of
ubiquitination, and it has been
shown that p53
protein levels are
downregulated by...
- MAPK1, PRMT5, CDK1, CDK4, β-catenin, and UBXD8 have been
identified as
ubiquitination targets Typically, a
fetus inherits a
maternal copy of UBE3A and a paternal...
-
system exclusively involved in
removing damaged protein from the cell,
ubiquitination and
subsequent protein degradation by the
proteasome is now perceived...
