- SV, et al. (June 2013). "The ubiquitin-conjugating
enzyme (E2) Ube2w
ubiquitinates the N
terminus of substrates". The
Journal of
Biological Chemistry....
-
proline residues within the HIF1α protein. pVHL is an E3
ligase that
ubiquitinates HIF1α and
causes its
degradation by the proteasome. In low
oxygen conditions...
- E6-****ociated protein,
which has
ubiquitin ligase activity, acts to
ubiquitinate p53,
leading to its
proteosomal degradation. E7 (in
oncogenic HPVs) acts...
-
memory of
silenced region after cellular differentiation. PRC1 also mono-
ubiquitinates histone H2A on
lysine 119 (H2AK119Ub1).
These proteins are required...
- they can be
organized into one place.
Since Lewy
bodies are made of
ubiquitinated proteins that
would be
handled in the ubiquitin-proteasome pathway,...
-
recognition complex. In G1,
levels of
geminin are kept low by the APC,
which ubiquitinates geminin to
target it for degradation. When
geminin is destro****, Cdt1...
- ubiquitination.
Cullin 3
ubiquitinates NRF2,
while Keap1 is a
substrate adaptor protein that
facilitates the reaction. Once NRF2 is
ubiquitinated, it is transported...
-
aberrant ac****ulations of proteins,
including amyloid-β (Aβ), tau,
ubiquitinated proteins,
apolipoprotein E, and β-synuclein in
skeletal muscle. ......
- The
receptor will
thereby remain permanently antagonized until it is
ubiquitinated and thus destro****. A non-competitive
antagonist is a type of insurmountable...
-
processing of
different kinds of
misfolded proteins (e.g.
ubiquitinated vs. non-
ubiquitinated proteins).
Segregation of
toxic protein aggregates into JUNQ...
