-
phase by the
protein geminin,
which inhibits it, and by SCFSKP2,
which ubiquinates the
protein to tag it for
proteasomal degradation. This
regulation is...
- Subsequently,
proteins IKZF1, IKZF3, and CK1α are
recruited to the complex,
ubiquinated, and then
degraded by the proteasome. IKZF1 and IKZF3 are
essential transcription...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
- ubiquitin-proteasome
system (UPS). This
consists of an E1-E2-E3
pathway that
ubiquinates proteins to mark them for degradation. In eukaryotes, the
proteins get...
-
certain apoptotic pathways, and if absent,
leads to the
formation of
ubiquinated inclusions.
Experiments in mice with
neuronally confined macroautophagy-gene...
-
irrelevant example: Dot1*‡ –
Methylates lysine 79 of
histone H3.) Bre1 –
Ubiquinates (adds
ubiquitin to)
lysine 123 of
histone H2B. ****ociated with pre-initiation...
-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
-
healthy mitochondria.
Parkin is
therefore required before mitophagy as it
ubiquinates Mfn1/2,
labelling it for
proteasomal degradation.
Proteomic studies identified...
-
Degradation of LDL
Receptor Protein (IDOL) is a
ubiquitin ligase that
ubiquinates LDL
receptors in
endosomes and
directs the
receptors to the lysosomal...
-
ubiquitin E3
ligase complex,
allowing for the non-functional
ribosomes to be
ubiquinated before being degraded.
Prokaryotes lack a
homolog for Mms1, so it is...
