-
activates (phosphorylates) CHEK2 and FANCD2 CHEK2
phosphorylates BRCA1.
Ubiquinated FANCD2
complexes with BRCA1 and RAD51. The PALB2
protein acts as a hub...
- Subsequently,
proteins IKZF1, IKZF3, and CK1α are
recruited to the complex,
ubiquinated, and then
degraded by the proteasome. IKZF1 and IKZF3 are
essential transcription...
- mono-ubiquitinated isoform. In normal, non-mutant cells, FANCD2 is mono-
ubiquinated in
response to DNA damage.
FANCE together with
FANCC acts as the substrate...
-
certain apoptotic pathways, and if absent,
leads to the
formation of
ubiquinated inclusions.
Experiments in mice with
neuronally confined macroautophagy-gene...
-
reductase has not been demonstrated).
Lysine residues 89 and 248 can
become ubiquinated by ER-resident E3 ligases. The
identity of the
multiple E3
ligases involved...
-
Ubiquilin 2 enzyme. This non-functioning
enzyme leads to the ac****ulation of
ubiquinated proteins in the
lower motor neurons and
upper corticospinal motor neurons...
-
ubiquitinates RIP1 and
induces constitutive RIP1
ubiquitination in
cancer cells.
Ubiquinated RIP1 ****ociates with the
prosurvival kinase TAK1. When this
complex is...
-
ubiquitin E3
ligase complex,
allowing for the non-functional
ribosomes to be
ubiquinated before being degraded.
Prokaryotes lack a
homolog for Mms1, so it is...
- The E3
ubiquitin ligase is able to
recognize misfolded proteins and
ubiquinate them. HDAC6 can then bind to the
ubiquitin and the
motor protein dynein...
- for the
proteasome by N-terminus ubiquitylation.
Proteins are
usually ubiquinated at
lysine residues.
Human [[p14ARF]], however, does not
contain any lysines...
