-
upstream open
reading frame (
uORF) is an open
reading frame (ORF)
within the 5'
untranslated region (5'UTR) of an mRNA.
uORFs can
regulate eukaryotic gene...
-
coding sequence or
other uORFs that may
exist on the same transcript. The
translation of the
protein within the main ORF
after a
uORF sequence has been translated...
-
uORFs. However, less than 10% of the
vertebrate mRNAs surve**** in an
older study contained AUG
codons in
front of the
major ORF. Interestingly,
uORFs...
- The
uORFs closest to the 5′ cap
protect the CDS from the
inhibitory activities of the
downstream uORFs located closer to the CDS. In summary,
uORFs generally...
- the
corresponding uORF is then translated. The
translated uORF could be a NMD candidate,
although studies have
shown that some
uORFs can
avoid NMD. The...
-
untranslated regions, and do not form the protein-coding
region of the gene,
uORFs located within the 5' UTR can be
translated into peptides. The 5' UTR is...
-
could result in
translation of so-called
upstream Open
Reading Frames (
uORFs).
uORF translation usually results in the
synthesis of
short polypeptides, some...
-
mechanism is used to
regulate eukaryotic genes,
which is
referred to as
uORFs (upstream open
reading frames).
Signal peptide is a
potential (therapeutic)...
- post-termination ribosomes. In
specialized cases of
reinitiation following uORFs, eIF3 may
remain bound to the
ribosome through elongation and termination...
- different. 'Good proteins' are pink,
partial or not-good
proteins are yellow,
uORFs are green. 5' cap or3' poly A
flags show
completeness of the transcript...
