-
Tropinone is an alkaloid,
famously synthesised in 1917 by
Robert Robinson as a
synthetic precursor to atropine, a
scarce commodity during World War I...
-
species all
contain two
types of the
reductase enzymes,
tropinone reductase I and
tropinone reductase II. TRI
produces tropine and TRII
produces pseudotropine...
- reaction.
Hygrine further rearranges to
tropinone. Subsequently,
tropinone reductase I (EC 1.1.1.206)
converts tropinone to
tropine which condenses with phenylalanine-derived...
- In enzymology, a
tropinone reductase II (EC 1.1.1.236) is an
enzyme that
catalyzes the
chemical reaction pseudotropine + NADP+ ⇌ {\displaystyle \rightleftharpoons...
- In enzymology, a
tropinone reductase I (EC 1.1.1.206) is an
enzyme that
catalyzes the
chemical reaction tropine + NADP+ ⇌ {\displaystyle \rightleftharpoons...
- molecule.
Retrosynthetic analysis was used as
early as 1917 in Robinson's
Tropinone total synthesis.
Important conceptual work on
retrosynthetic analysis...
- book The Art and
Science of
Chess (Batsford, 1972). His
synthesis of
tropinone (a
precursor for
atropine & benztropine) in 1917 was not only a big step...
-
methanolysis followed by
reaction with
methylamine and succinaldehyde.
Tropinone Findlay,
Stephen P. (1957). "Concerning 2-Carbomethoxytropinone*". The...
-
chemical yield. An
example of a one-pot
synthesis is the
total synthesis of
tropinone or the G****man
indole synthesis.
Sequential one-pot
syntheses can be used...
- this reaction.
Hygrine further rearranges to
tropinone. Subsequently,
tropinone reductase I
converts tropinone to tropine,
which condenses with phenylalanine-derived...
