Definition of Topoisomerases. Meaning of Topoisomerases. Synonyms of Topoisomerases

- DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms...
- broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII). Topoisomerase plays important roles in cellular reproduction...
- Type II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use...
- two structurally and mechanistically distinct topoisomerases: type IA and type IB. Type IA topoisomerases change the linking number of a circular DNA strand...
- Topoisomerase IV is one of two Type II topoisomerases in bacteria, the other being DNA gyrase. Like gyrase, topoisomerase IV is able to p**** one double-strand...
- reside on chromosomes 1 and 22. As reviewed by Champoux, the type IB topoisomerases, including TOP1, form a covalent intermediate in which the active site...
- creates a torsional load that would eventually stop the replication fork. Topoisomerases are enzymes that temporarily break the strands of DNA, relieving the...
- simply gyrase, is an enzyme within the class of topoisomerase and is a subclass of Type II topoisomerases that reduces topological strain in an ATP dependent...
- mechanism of action which involves inhibition of bacterial type II topoisomerases. Zoliflodacin is being developed as part of a public-private partnership...
- proteins for degradation by the proteasome. 16 topoisomerase inhibitors unsilence paternal UBE3A. Topoisomerases are enzymes that regulate the unwinding of...