-
Thymidylate synthase (TS) (EC 2.1.1.45) is an
enzyme that
catalyzes the
conversion of
deoxyuridine monophosphate (dUMP) to
deoxythymidine monophosphate...
-
Thymidine monophosphate (TMP), also
known as
thymidylic acid (conjugate base
thymidylate),
deoxythymidine monophosphate (dTMP), or
deoxythymidylic acid (conjugate...
-
Thymidylate kinase (EC 2.7.4.9; dTMP kinase)
catalyzes the
phosphorylation of
thymidine 5'-monophosphate (dTMP) to form
thymidine 5'-diphosphate (dTDP)...
-
Thymidylate synthase inhibitors are
chemical agents which inhibit the
enzyme thymidylate synthase and have
potential as an
anticancer chemotherapy. This...
- The
enzyme thymidylate 5′-phosphatase (EC 3.1.3.35)
catalyzes the
reaction thymidylate + H2O ⇌ {\displaystyle \rightleftharpoons }
thymidine + phosphate...
- depletion. High
levels of
thymidylate were
observed to be
mutagenic and recombinogenic,
whereas starvation for
thymidylate was
recombinogenic but only...
-
entirely clear, but it is
believed to
involve blocking the
action of
thymidylate synthase and thus
stopping the
production of DNA.
Fluorouracil was patented...
- In enzymology, a
thymidylate synthase (FAD) (EC 2.1.1.148) is an
enzyme that
catalyzes the
chemical reaction 5,10-methylenetetrahydrofolate + dUMP + FADH2...
- in the
detoxification of formaldehyde. It is the one-carbon
donor for
thymidylate synthase, for
methylation of 2-deoxy-uridine-5-monophosphate (dUMP) to...
-
growth and
replication because it is used in DNA synthesis,
primarily at
thymidylate and
purine biosynthesis, and
amino acids synthesis,
including serine...
