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Thromboxane is a
member of the
family of
lipids known as eicosanoids. The two
major thromboxanes are
thromboxane A2 and
thromboxane B2. The distinguishing...
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Thromboxane A2 (TXA2) is a type of
thromboxane that is
produced by
activated platelets during hemostasis and has
prothrombotic properties: it stimulates...
-
thromboxanes is due to its
irreversible inactivation of the
cyclooxygenase (COX) enzyme.
Cyclooxygenase is
required for
prostaglandin and
thromboxane...
- 1111/bph.12677. PMC 4080968. PMID 24646155. Shen RF, Tai HH (1998). "
Thromboxanes:
synthase and receptors". J
Biomed Sci. 5 (3): 153–72. doi:10.1007/BF02253465...
- to
various prostaglandins, to prostacyclin, to
thromboxanes, and to the 17-carbon
product of
thromboxane metabolism of
prostaglandin G2/H2, 12-hydroxyheptadecatrienoic...
- well as
regulating the
contraction of
smooth muscle tissue. Conversely,
thromboxanes (produced by
platelet cells) are
vasoconstrictors and
facilitate platelet...
-
prostaglandins (mediators of
inflammatory and
anaphylactic reactions), the
thromboxanes (mediators of vasoconstriction), and the
prostacyclins (active in the...
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Thromboxane B2 (TXB2) is an
inactive metabolite/product of
thromboxane A2. It is
almost completely cleared in the urine. It
itself is not
involved in platelet...
-
thromboxanes is
important in the body,
particularly because these two
eicosanoids exert opposing effects. In
catalyzing the
synthesis of
thromboxanes...
- London,
showed aspirin suppressed the
production of
prostaglandins and
thromboxanes. For this
discovery he was
awarded the 1982
Nobel Prize in Physiology...
