-
Thromboxane is a
member of the
family of
lipids known as eicosanoids. The two
major thromboxanes are
thromboxane A2 and
thromboxane B2. The distinguishing...
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Thromboxane A2 (TXA2) is a type of
thromboxane that is
produced by
activated platelets during hemostasis and has
prothrombotic properties: it stimulates...
- The
thromboxane receptor (TP) also
known as the
prostanoid TP
receptor is a
protein that in
humans is
encoded by the TBXA2R gene, The
thromboxane receptor...
-
Thromboxane A
synthase 1 (EC 5.3.99.5, platelet,
cytochrome P450,
family 5,
subfamily A), also
known as TBXAS1, is a
cytochrome P450
enzyme that, in humans...
- well as
regulating the
contraction of
smooth muscle tissue. Conversely,
thromboxanes (produced by
platelet cells) are
vasoconstrictors and
facilitate platelet...
-
effective vasodilator. Prostacyclin's
interactions contrast with
those of
thromboxane (TXA2),
another eicosanoid. Both
molecules are
derived from arachidonic...
-
responsible for
thromboxane A2 synthesis. This
dense tubular system is
connected to the
surface platelet membrane to aid
thromboxane A2 release. Circulating...
-
thromboxanes is due to its
irreversible inactivation of the
cyclooxygenase (COX) enzyme.
Cyclooxygenase is
required for
prostaglandin and
thromboxane...
-
Thromboxane B2 (TXB2) is an
inactive metabolite/product of
thromboxane A2. It is
almost completely cleared in the urine. It
itself is not
involved in platelet...
- London,
showed aspirin suppressed the
production of
prostaglandins and
thromboxanes. For this
discovery he was
awarded the 1982
Nobel Prize in Physiology...
