Definition of Thiopurine. Meaning of Thiopurine. Synonyms of Thiopurine

- Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus...
- is especially common in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk...
- The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease...
- deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine is in the thiopurine and antimetabolite...
- checked w****ly when on the medication. People with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Avoiding pregnancy...
- dose reduction of the thiopurine, usually to one-third of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase....
- rapidly, alongside another medication such as either methotrexate or a thiopurine to prevent recurrence. Cessation of smoking is recommended for people...
- regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are ****ociated with thiopurine-induced...
- and procainamide. Inheriting abnormal thiopurine S-methyltransferase may affect the metabolism of the thiopurine drugs mercaptopurine and azathioprine...
- done to identify variation in thiopurine response. The EMR stores quantitative value of IBD patient's TPMT (thiopurine S-methyltransferase) activity,...