Definition of Thiopurine. Meaning of Thiopurine. Synonyms of Thiopurine

Here you will find one or more explanations in English for the word Thiopurine. Also in the bottom left of the page several parts of wikipedia pages related to the word Thiopurine and, of course, Thiopurine synonyms and on the right images related to the word Thiopurine.

Definition of Thiopurine

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Meaning of Thiopurine from wikipedia

- Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus...
- is especially common in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk...
- The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease...
- deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine is in the thiopurine and antimetabolite...
- checked w****ly when on the medication. People with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Avoiding pregnancy...
- dose reduction of the thiopurine, usually to one-third of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase....
- rapidly, alongside another medication such as either methotrexate or a thiopurine to prevent recurrence. Cessation of smoking is recommended for people...
- and procainamide. Inheriting abnormal thiopurine S-methyltransferase may affect the metabolism of the thiopurine drugs mercaptopurine and azathioprine...
- regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are ****ociated with thiopurine-induced...
- done to identify variation in thiopurine response. The EMR stores quantitative value of IBD patient's TPMT (thiopurine S-methyltransferase) activity,...