-
adjacent to a
carbonyl group.
Thiolactones can be
prepared by
dehydration of thiol-containing
carboxylic acids.
Thiolactones can be
hydrolyzed back to the...
-
Homocysteine thiolactone (HTL) is an
organosulfur compound with the
formula H2NCHC(O)SCH2CH2. It is the
thiolactone (intramolecular thioester) of homocysteine...
-
protein for degradation.
Oxidation of the
sulfur atom in
thioesters (
thiolactones) is
postulated in the
bioactivation of the
antithrombotic prodrugs ticlopidine...
- for
methionine synthase.
Homocysteine can
cyclize to give
homocysteine thiolactone, a five-membered heterocycle.
Because of this "self-looping" reaction...
- CYP2C19, CYP2C9, CYP2B6, and CYP3A. The
thiophene ring is
converted to a
thiolactone,
which undergoes ring-opening. The
active metabolite has
three sites...
-
intestine and
carboxylesterase 1 in the
liver to a
likewise inactive thiolactone,
which is then
converted by CYP3A4 and CYP2B6, and to a
minor extent...
- A/B-corrin-ring
closure was also
achieved by
converting the
thiolactone-thiolactame
intermediate HE-40u to
thiolactone-thioiminoester HE-45u by S-methylation of the...
-
hydrolysing a wide
variety of substrates, such as lactones,
including thiolactones and
pharmaceutical agents such as statins. PON1
substrates also include...
- acid: a
novel mucolytic agent of the
class of
homocysteine thiolactone derivatives". Il Farmaco;
Edizione Scientifica. 41 (1): 69–79. PMID 3956722...
- (+)-biotin. In this case, the ****uyama
coupling takes place with the
thiolactone: The
Barbier reaction involves nucleophilic addition of a
carbanion equivalent...
