-
Tetrahydrofolic acid (THFA), or
tetrahydrofolate, is a
folic acid derivative. In humans,
tetrahydrofolic acid is
produced from
dihydrofolic acid by dihydrofolate...
- is used in the
methylation of
homocysteine to form
methionine and
tetrahydrofolate (THF). THF is the
immediate acceptor of one
carbon unit for the synthesis...
-
NADPH as an
electron donor,
which can be
converted to the
kinds of
tetrahydrofolate cofactors used in one-carbon
transfer chemistry. In humans, the DHFR...
- the
cofactor pyridoxal phosphate:
serine +
tetrahydrofolate →
glycine + N5,N10-methylene
tetrahydrofolate + H2O In E. coli,
antibiotics that
target folate...
- 10-Formyltetrahydrofolate (10-CHO-THF) is a form of
tetrahydrofolate that acts as a
donor of
formyl groups in anabolism. In
these reactions 10-CHO-THF...
- enzymology, a formate—
tetrahydrofolate ligase (EC 6.3.4.3) is an
enzyme that
catalyzes the
chemical reaction ATP +
formate +
tetrahydrofolate ⇌ {\displaystyle...
-
methylenetetrahydrofolate reductase (MTHFR) It is
mainly produced by the
reaction of
tetrahydrofolate with serine,
catalyzed by the
enzyme serine hydroxymethyltransferase...
- 5,10-Methenyltetrahydrofolate (5,10-CH=THF) is a form of
tetrahydrofolate that is an
intermediate in metabolism. 5,10-CH=THF is a
coenzyme that accepts...
-
Tetrahydrofolate riboswitches are a
class of
homologous RNAs in
certain bacteria that bind
tetrahydrofolate (THF). It is
almost exclusively located in...
- 3-methyl-2-oxobutanoate + H2O ⇌ {\displaystyle \rightleftharpoons }
tetrahydrofolate + 2-dehydropantoate The 3
substrates of this
enzyme are 5...
