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Tankyrase, also
known as
tankyrase 1, is an
enzyme that in
humans is
encoded by the TNKS gene. It
inhibits the
binding of TERF1 to
telomeric DNA. Tankyrase...
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Tankyrase-2 is an
enzyme that in
humans is
encoded by the TNKS2 gene. TNKS2 has been
shown to
interact with GRB14, TERF1 and
Cystinyl aminopeptidase....
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structure and
function within the cell. PARP1, PARP2,
VPARP (PARP4),
Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a
confirmed PARP...
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inhibitor 1), TINF2 (TERF1-interacting
telomerase nuclear factor), TNKS2 (
Tankyrase, an enzyme) and NME1 (nucleoside
diphosphate kinase).In conclusion, as...
- tyrosine-protein
kinase LCK PCM1,
Pericentriolar material 1
protein TNKS,
Tankyrase-1 TNKS2,
Tankyrase-2 TUBE1,
Tubulin epsilon chain PCNT, pericentrin, a
matrix scaffold...
- PMC 1069602. PMID 15798198. Bae J,
Donigian JR,
Hsueh AJ (February 2003). "
Tankyrase 1
interacts with Mcl-1
proteins and
inhibits their regulation of apoptosis"...
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Immortality Maximum life span
Rejuvenation (aging) Senescence,
biological aging Tankyrase Telomere-binding
protein G-quartet
Immortal DNA
strand hypothesis During...
- Importantly,
activity in the β-catenin
destruction complex can be
increased by
tankyrase inhibitors and are a
potential therapeutic option to
reduce the growth...
- that
results in
decreased proteasome activity. (ADP-ribosyl)transferase
Tankyrase (TNKS)
causes ADP-ribosylation of PI31
which in turn
increases the proteasome...
-
Sutherland G R; Daly R J (May 2001). "Identification of a
novel human tankyrase through its
interaction with the
adaptor protein Grb14". J. Biol. Chem...
