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Synaptophysin, also
known as the
major synaptic vesicle protein p38, is a
protein that in
humans is
encoded by the SYP gene. The gene is
located on the...
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SCLCs bear the
markers of
neuroendocrine cells, such as chromogranin,
synaptophysin, and CD56.
Adenocarcinomas tend to
express Napsin-A and TTF-1; squamous...
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neuroendocrine tumor 5%
Multiple nests of
tumor cells Gastrinoma Chromogranin Synaptophysin MEN1 DAXX/ATRX Pre-cancer
below for comparison: Precancer: Intraductal...
- BDNF expression,
matrix metalloproteinase activity, and
expression of
synaptophysin.
Anoxic depolarization in the
brain CADASIL Cerebrovascular disease...
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chief cells located in the cell
balls are
positive for chromogranin,
synaptophysin,
neuron specific enolase, serotonin,
neurofilament and
Neural cell adhesion...
- 5-hydroxyindoleacetic acid (5-HIAA) neuron-specific
enolase (NSE, gamma-gamma dimer)
synaptophysin (P38)
Newer markers include N-terminally
truncated variant of Hsp70...
- <9% null cell
adenomas do not
secrete hormones may
stain positive for
synaptophysin Asymptomatic or
hypogonadism 25% of
pituitary adenomas are nonsecretive...
- key
difference between synaptic vesicles and
LDCVs is that
protein synaptophysin which is
present in the
membrane of
synaptic vesicles is
absent in LDCVs...
- biopsy,
immunohistochemistry is
generally positive for
chromogranin and
synaptophysin.
Genetic testing thereof typically shows altered MEN1 and DAXX/ATRX...
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including epidermal marker cytokeratin 20 and
neuroendocrine markers synaptophysin and
chromogranin A. Furthermore, the ion
channel Piezo2 and transcription...
