-
Spironolactone, sold
under the
brand name
Aldactone among others, is a
diuretic medication primarily used to
treat fluid build-up due to
heart failure...
- The
pharmacodynamics of
spironolactone, an
antimineralocorticoid and
antiandrogen medication,
concern its
mechanisms of action,
including its biological...
-
combination with
other drugs, for the
management of
chronic heart failure.
Spironolactone, the
first member of the class, is also used in the
management of hyperaldosteronism...
-
antagonists can also be used for
treatment of
primary hyperaldosteronism.
Spironolactone, a
steroidal aldosterone antagonist, is also used in
management of female...
-
derived from
spironolactone by the
introduction of a 9α,11α-epoxy
bridge and by
substitution of the 17α-thoacetyl
group of
spironolactone with a carbomethoxy...
- Generally, the
starting dose is oral
spironolactone 100 mg/day (max 400 mg/day). 40% of
people will
respond to
spironolactone. For nonresponders, a loop diuretic...
-
inhibitors finasteride and
dutasteride and the
steroidal AR
antagonist spironolactone have been ****ociated with
significantly reduced risk of
prostate cancer...
- (RALES)
trial is a
landmark clinical study that ****essed the
impact of
spironolactone, an
aldosterone antagonist, on
morbidity and
mortality in
patients with...
- and
spironolactone has
mixed and
inconsistent effects on
hormone levels. In any case,
testosterone levels are
usually unchanged by
spironolactone. Studies...
- to
spironolactone which is used as a
diuretic in Europe,
including in
Italy and Belgium. It is also an
important active metabolite of
spironolactone, and...
