-
important phospholipid.
Sphingosine can be
phosphorylated in vivo via two kinases,
sphingosine kinase type 1 and
sphingosine kinase type 2. This leads...
- from the
precursor sphingolipid sphingosine.
Sphingolipid metabolites, such as ceramide,
sphingosine and
sphingosine-1-phosphate, are
lipid second messengers...
-
Sphingosine kinase 1 is an
enzyme that in
humans is
encoded by the SPHK1 gene.
Sphingosine kinase 1
phosphorylates sphingosine to
sphingosine-1-phosphate...
-
Sphingosine-1-phosphate (S1P) is a
signaling sphingolipid, also
known as lysosphingolipid. It is also
referred to as a
bioactive lipid mediator. Sphingolipids...
- enzymology, a
sphingosine cholinephosphotransferase (EC 2.7.8.10) is an
enzyme that
catalyzes the
chemical reaction CDP-choline +
sphingosine ⇌ {\displaystyle...
-
Liotta DC,
Merrill AH (August 2008). "Biodiversity of
sphingoid bases ("
sphingosines") and
related amino alcohols".
Journal of
Lipid Research. 49 (8): 1621–39...
-
Sphingosine-1-phosphate
receptor 1 (S1P
receptor 1 or S1PR1), also
known as
endothelial differentiation gene 1 (EDG1) is a
protein that in
humans is encoded...
-
coordinated for this purpose.
Sphingosine kinase (SK) is a
lipid kinase that
catalyzes the
conversion of
sphingosine to
sphingosine-1-phosphate (S1P). Sphingolipids...
-
Sphingosine-1-phosphate
receptor modulators are a
class of
drugs that
interact with S1P receptors, a
family of G protein-coupled
receptors involved in...
- medication, used for the
treatment of
multiple sclerosis.
Fingolimod is a
sphingosine-1-phosphate
receptor modulator,
which sequesters lymphocytes in lymph...
