-
Sortilin (SORT1) is a
protein that in
humans is
encoded by the SORT1 gene on
chromosome 1. This
protein is a type I
membrane glycoprotein in the vacuolar...
-
Sortilin-related receptor, L(DLR class) A
repeats containing is a
protein that in
humans is
encoded by the SORL1 gene. SORL1 (also
known as SORLA, SORLA1...
-
surface expression of low-affinity
nerve growth factor receptor (p75).
Sortilin is
required for many apoptosis-promoting p75NTR reactions, functioning...
- and Bak. The
importance of
sortilin in p75NTR-mediated
apoptosis is
exhibited by the fact that the
inhibition of
sortilin expression in
neurons expressing...
- and
survival of the
target neuron. High
affinity binding between proNGF,
sortilin, and p75NTR can
result in
either survival or
programmed cell death. Study...
-
amino acid
change occurs on the
portion of the
prodomain where sortilin binds; and
sortilin is
essential for
normal trafficking. The Val66Met
mutation results...
- (June 2011). "
Sortilin: an
unusual suspect in
cholesterol metabolism: from GWAS
identification to in vivo
biochemical analyses,
sortilin has been identified...
- PCSK9 co-localizes with the
protein sortilin on its way
through the
Golgi and trans-Golgi complex. A PCSK9-
sortilin interaction is
proposed to be required...
- The SorCS2 (
sortilin-related Vps10p
domain containing receptor 2) gene is
found on
chromosome 4 (4p16.1), and is
composed of 28 exons. The N-terminal exons...
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Recent research into co-receptors for p75, such as the
sortilin co-receptor, has
implicated sortilin in
connection to neurotrophins, a type of
nerve growth...
