Definition of Smoothened. Meaning of Smoothened. Synonyms of Smoothened

- Smoothened is a protein that in humans is encoded by the SMO gene. Smoothened is a class Frizzled (class F) G protein-coupled receptor that is a component...
- Smoothened agonist (SAG) was one of the first small-molecule agonists developed for the protein Smoothened, a key part of the hedgehog signaling pathway...
- leads to increased levels of Smoothened is not clear (Step 1 in Figure 3). Following binding of Hh to Patched, Smoothened levels increase greatly over...
- sterol-sensing domain in patched, which then inhibits the activity of smoothened. Smoothened is a G protein-coupled receptor, most of which is stored in membrane...
- treat cancer. Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism). It was approved for medical use in the United States and...
- treatment. These include vismodegib and sonidegib, both inhibitors of Smoothened (SMO), which are being used for the treatment of basal cell carcinoma...
- In statistics and image processing, to smooth a data set is to create an approximating function that attempts to capture important patterns in the data...
- the "Smoothened" protein, by which the Hedgehog signal can be transduced. In the absence of Hedgehog, the Patched receptor inhibits Smoothened action...
- skin together at the middle of it. This is what we call navel today. He smoothened the wrinkles and shaped the chest. But he made sure to leave a few wrinkles...
- radiation. The substance acts as a cyclopamine-competitive antagonist of the smoothened receptor (SMO) which is part of the Hedgehog signaling pathway. SMO inhibition...