-
working on
these molecules (by convention,
Siglecs are
always capitalised.)
Several additional Siglecs (
Siglecs 5–12) have been
identified in
humans that...
-
motif is
critical for the
inhibitory signaling mediated by
Siglecs-7 and -9, CD33-related
Siglecs expressed on
human monocytes and NK cells". J. Immunol....
- tail
compared to most CD33-****ociated
siglecs. Subsequently, a
longer form of
Siglec-8,
initially termed Siglec-8L, that
contains 499
amino acid residues...
-
these osteoblasts can
worsen tumors in two ways. First, they can
induce SiglecFhigh-expressing
neutrophil formation that in turn
promotes lung
tumor growth...
- CD33 or
Siglec-3 (sialic acid
binding Ig-like
lectin 3, SIGLEC3,
SIGLEC-3, gp67, p67) is a
transmembrane receptor expressed on
cells of
myeloid lineage...
- (Heat-stable antigen).
SIGLECs are
members of the
immunoglobulin superfamily that are
expressed on the cell surface. Most
SIGLECs have 1 or more cytoplasmic...
-
Sialic acid
binding Ig-like
lectin 15 (
Siglec-15) is a
protein that in
humans is
encoded by the SIGLEC15 gene.
Siglec-15 is
predominately expressed on osteoclasts...
- neutrophils, macrophages,
dendritic cells and
activated T-cells (SIGLEC9).
SIGLECs 7 and 9
suppress the
immune function of
these cells by
binding to terminal...
-
mammalian glycan-binding
proteins (GBPs): C-type lectin, galectin, and
SIGLEC immune receptors that bind carbohydrates: CD1, T cell receptor, and anti-carbohydrate...
- its N-terminus. It is a
member of the
immunoglobulin superfamily and the
SIGLEC family. CD22
functions as an
inhibitory receptor for B cell
receptor (BCR)...
