-
working on
these molecules (by convention,
Siglecs are
always capitalised.)
Several additional Siglecs (
Siglecs 5–12) have been
identified in
humans that...
- (Heat-stable antigen).
SIGLECs are
members of the
immunoglobulin superfamily that are
expressed on the cell surface. Most
SIGLECs have 1 or more cytoplasmic...
- tail
compared to most CD33-****ociated
siglecs. Subsequently, a
longer form of
Siglec-8,
initially termed Siglec-8L, that
contains 499
amino acid residues...
-
Sialoadhesin (
SIGLEC-1) is a cell
adhesion molecule found on the
surface of
various immune cells. It is
found in
especially high
amounts on macrophages...
- CD33 or
Siglec-3 (sialic acid
binding Ig-like
lectin 3, SIGLEC3,
SIGLEC-3, gp67, p67) is a
transmembrane receptor expressed on
cells of
myeloid lineage...
-
motif is
critical for the
inhibitory signaling mediated by
Siglecs-7 and -9, CD33-related
Siglecs expressed on
human monocytes and NK cells". J. Immunol....
-
Crocker PR,
Saito H,
Bochner BS (June 2006). "Alteration and
acquisition of
Siglecs during in
vitro maturation of CD34+
progenitors into
human mast cells"...
-
Sialic acid
binding Ig-like
lectin 15 (
Siglec-15) is a
protein that in
humans is
encoded by the SIGLEC15 gene.
Siglec-15 is
predominately expressed on osteoclasts...
- (March 2021). "The
clinical impact of glycobiology:
targeting selectins,
Siglecs and
mammalian glycans".
Nature Reviews. Drug Discovery. 20 (3): 217–243...
-
these osteoblasts can
worsen tumors in two ways. First, they can
induce SiglecFhigh-expressing
neutrophil formation that in turn
promotes lung
tumor growth...
