-
principle any gene can be
knocked down by a
synthetic siRNA with a
complementary sequence,
siRNAs are an
important tool for
validating gene
function and...
- long double-stranded
RNA (ds
RNA)
molecules into
short double-stranded
fragments of
approximately 21 to 23
nucleotide siRNAs. Each
siRNA is
unwound into two...
-
first known components of
RNA interference and
their paralogs,
Dicer and the PIWI proteins, are used by both mi
RNAs and
siRNAs. Ruvkun's lab in 2003 identified...
-
transcribed m
RNAs (IVT-m
RNA) have been used to
deliver proteins for bone regeneration, pluripotency, and
heart function in
animal models.
SiRNAs,
short RNA molecules...
-
interfering RNAs (
siRNAs) are
similar in
function to mi
RNAs; they come from
other sources of
RNA, but
serve a
similar purpose to mi
RNAs.
Given their...
- sequence-specific
cleavage of
target m
RNA. Ta-
siRNAs are
classified as
siRNA because they
arise from double-stranded
RNA (ds
RNA). ta-
siRNA were
originally detected...
-
intermediate RNA, they are
targeted by a
dicer enzyme and
cleaved into
siRNAs that are then
loaded onto the
RNA-induced
silencing complex. The
viroid siRNAs contain...
- the m
RNA. mi
RNAs resemble the
small interfering RNAs (
siRNAs) of the
RNA interference (RNAi) pathway,
except mi
RNAs derive from
regions of
RNA transcripts...
- of
small RNA have
currently been identified, namely:
small interfering RNA (
siRNA), micro
RNA (mi
RNA), and piwi-interacting
RNA (pi
RNA).
siRNAs act in the...
-
triggers m
RNA degradation by 5' decapping, 3' poly(A) tail removal, or
endonucleolytic cleavage. In metazoans,
small interfering RNAs (
siRNAs) processed...
