- by
several proteins,
collectively referred to as the
shelterin complex. In humans, the
shelterin complex consists of six
proteins identified as TRF1,...
-
Shelterin (also
called telosome) is a
protein complex known to
protect telomeres in many
eukaryotes from DNA
repair mechanisms, as well as to regulate...
- and is
encoded in
humans by the TERF2 gene. It is a
component of the
shelterin nucleoprotein complex and a
second negative regulator of
telomere length...
- 6-nucleotide
sequences that cap the ends of chromosomes.
TERRA functions with
shelterin to
inhibit telomere lengthening by
enzyme telomerase. However,
other studies...
-
length at a rate of
approximately 25
nucleotides per year. The telomere-
shelterin complexes that cap all
eukaryotic chromosomes ensure that
healthy cells...
-
important role in
regulating total TERRA expression. Additionally, the
Shelterin component TRF1 has been
shown to
support TERRA transcription. As part...
- TPP1 gene, also
known as CLN2. TPP1
should not be
confused with the TPP1
shelterin protein which protects telomeres and is
encoded by the ACD gene. Mutations...
- that in
humans is
encoded by the TINF2 gene. TINF2 is a
component of the
shelterin protein complex found at the end of telomeres. TINF2 has been
shown to...
-
forming a
complex known as
shelterin.
There are six
subunits forming the telomere-binding
protein complex known as
shelterin: TERF1, TERF2, POT1, TIN2...
- sequenced. The
shelterin protein TPP1 is both
necessary and
sufficient to
recruit the
telomerase enzyme to telomeres, and is the only
shelterin protein in...
