- A
senolytic (from the
words senescence and -lytic, "destroying") is
among a
class of
small molecules under basic research to
determine if they can selectively...
-
hormonal therapy for
women under 50
years of age have not been determined. A
senolytic (from the
words senescence and -lytic, "destroying") is
among a class...
-
diabetes and atherosclerosis. This has
motivated researchers to
develop senolytic drugs to kill and
eliminate senescent cells to
improve health in the elderly...
- with less
clear biological pathways to
target aging include lipoic acid,
senolytics, and
coenzyme Q10.
While agents such as
these have some
limited laboratory...
-
product targeting ophthalmologic diseases. Both
products are
senolytic medicines.
Senolytics Calico Brueck,
Hilary (3
February 2016). "Mayo
Clinic Taps...
-
expressed p53 died in a
small period of time. Bcl-xL is a
target of
various senolytic agents.
Studies of cell
cultures of
senescent human umbilical vein endothelial...
-
treatment of
cardiac arrhythmias.
Cardiac glycosides were
identified as
senolytics: they can
selectively eliminate senescent cells which are more sensitive...
- dose-limiting.[citation needed] In
animal studies,
navitoclax was
found to be a
senolytic agent,
inducing apoptosis in senescent, but not non-senescent cells. Oral...
-
specifically target cellular senescence.
Senotherapeutics include emerging senolytic/senoptotic
small molecules that
specifically induce cell
death in senescent...
-
receptor is part of SASP, and has been used to
identify senescent cells for
senolytic therapy. Initially, SASP is
immunosuppressive (characterized by TGF-β1...
