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Securin is a
protein involved in
control of the metaphase-anaphase
transition and
anaphase onset.
Following bi-orientation of
chromosome pairs and inactivation...
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called securin for
destruction by
ubiquitylating it.
Securin is a
protein which inhibits a
protease known as separase. The
destruction of
securin unleashes...
- protein,
securin, for destruction.
Securin destruction liberates and
activates its
bound protease partner, separase.
Separase bound to
securin remains...
- The
three major targets for
degradation by the APC/C are
securin and S and M cyclins.
Securin releases separase, a protease, when degraded.
Separase then...
- APC/C), a
ubiquitin ligase which targets securin and
cyclin B for
degradation via the proteosome. As long as
securin and
cyclin B
remain active, separase...
- 2021,
structures of
human separase were
determined in
complex with
either securin or CDK1-cyclin B1-CKS1
using cryo-EM by
scientists of the
University of...
- " Up-regulated
genes in the
signature include: SNRPF, HNRPAB, DHPS and
securin. Actin,
myosin and MHC
class II down-regulation was also ****ociated with...
-
degrade cyclin B,
which harbors a D-box (destruction box), and to
break down
securin. The
latter is a
protein whose function is to
inhibit separase,
which in...
-
Securin is a
protein that in
humans is
encoded by the PTTG1 gene. The
encoded protein is a
homolog of
yeast securin proteins,
which prevent separins from...
- APC/CCdc20
protein complex has two main
downstream targets. Firstly, it
targets securin for destruction,
enabling the
eventual destruction of
cohesin and thus...
