Definition of Sclerostin. Meaning of Sclerostin. Synonyms of Sclerostin

- Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and...
- synthesize sclerostin, a secreted protein that inhibits bone formation by binding to LRP5/LRP6 coreceptors and blunting Wnt signaling. Sclerostin, the product...
- cardiovascular disease. It is a humanized monoclonal antibody that targets sclerostin. Research shows the drug increases bone formation and decreases bone resorption...
- Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene. This gene is a member of the sclerostin family and encodes...
- romosozumab (targets sclerostin, by Amgen), fresolimumab (TGF-β, Sanofi), blosozumab (sclerostin, Lilly), and setrusumab (sclerostin, begun by Novartis)...
- The gene involved is SOST, and by extension the protein involved is sclerostin. There have been attempts to relieve a patient suffering from van Buchem...
- (sold under the brand name Evenity) is a monoclonal antibody against sclerostin. Romosozumab is usually reserved for patients with very high fracture...
- Bollerslev J, van Hul W, et al. (August 2011). "Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in...
- monoclonal antibody Graves' ophthalmopathy 2020 Romosozumab (Evenity) Anti-sclerostin monoclonal antibody Osteoporosis 2019 2019 Ocrelizumab (Ocrevus) Anti-CD20...
- is caused by mutations in the SOST gene that encodes the sclerostin protein. The sclerostin protein is necessary in inhibiting the Wnt signaling pathway...