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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
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Activities of MDMA
Target Affinity (Ki, nM)
SERTTooltip Serotonin transporter 0.73–13,300 (Ki) 380–2,500 (IC50Tooltip half-maximal
inhibitory concentration)...
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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
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antagonist of the NMDA
receptor via the MK-801/PCPTooltip
phencyclidine site
SERTTooltip Serotonin transporter and
NETTooltip norepinephrine transporter blocker...
- σ2 ND TAAR1 450 (Ki) (rat) 10,000 (Ki) (mouse) >20,000 (EC50) (human)
SERTTooltip Serotonin transporter >30,000 (Ki) >100,000 (IC50Tooltip half-maximal...
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Molecular targets of
sertraline Site Ki (nM)
Species References SERTTooltip Serotonin transporter 0.15–3.3
Human NETTooltip Norepinephrine transporter...
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Chlorphenamine Site Ki (nM)
Species Ref
SERTTooltip Serotonin transporter 15.2
Human NETTooltip Norepinephrine transporter 1,440
Human DATTooltip Dopamine...
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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
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Quetiapine (and metabolite) Site QTP NQTP
Action Ref
SERTTooltip Serotonin transporter >10,000 927
Blocker NETTooltip Norepinephrine transporter >10,000...
- 792 TAAR1 1,400 (Ki) (rat) 17,000 (Ki) (mouse) >30,000 (EC50) (human)
SERTTooltip Serotonin transporter 3,800–>10,000 (Ki) 662–3,900 (IC50Tooltip half-maximal...
