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Activities of MDMA
Target Affinity (Ki, nM)
SERTTooltip Serotonin transporter 0.73–13,300 (Ki) 380–2,500 (IC50Tooltip half-maximal
inhibitory concentration)...
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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
- (mouse) 1,400 (EC50) (rat) 9,700 (EC50) (mouse) >20,000 (EC50) (human)
SERTTooltip Serotonin transporter >30,000 (Ki) >100,000 (IC50Tooltip half-maximal...
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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
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antagonist of the NMDA
receptor via the MK-801/PCPTooltip
phencyclidine site
SERTTooltip Serotonin transporter and
NETTooltip norepinephrine transporter blocker...
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Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
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Chlorphenamine Site Ki (nM)
Species Ref
SERTTooltip Serotonin transporter 15.2
Human NETTooltip Norepinephrine transporter 1,440
Human DATTooltip Dopamine...
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KORTooltip κ-Opioid
receptor >10,000 42,700–81,000 ≥450 1,800 (+))
Human Rat
SERTTooltip Serotonin transporter ~900 (IC50) 992–1,190 >20,000 (IC50) 2,980 ((−))...
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Mirtazapine Ki (nM)
Species Ref
SERTTooltip Serotonin transporter 10000+
Human NETTooltip Norepinephrine transporter 4600+
Human DATTooltip Dopamine transporter...
