-
Activities of MDMA
Target Affinity (Ki, nM)
SERTTooltip Serotonin transporter 0.73–13,300 (Ki) 380–2,500 (IC50Tooltip half-maximal
inhibitory concentration)...
- PCP site 1) and the common/main
sites on the
monoamine transporters (
SERTTooltip serotonin transporter,
DATTooltip dopamine transporter,
NETTooltip norepinephrine...
-
antagonist of the NMDA
receptor via the MK-801/PCPTooltip
phencyclidine site
SERTTooltip Serotonin transporter and
NETTooltip norepinephrine transporter blocker...
-
Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
-
Human 5-HT2A >10,000 ND
Human 5-HT2AHigh ≥5,000
Partial Agonist Rat
SERTTooltip Serotonin transporter 2,234
Inhibitor Human NETTooltip Norepinephrine...
-
Cyclobenzaprine (and metabolite) Site CBP NCBP
Action SERTTooltip Serotonin transporter 108 ND
Inhibitor NETTooltip Norepinephrine transporter 36 ND Inhibitor...
- (mouse) 1,400 (EC50) (rat) 9,700 (EC50) (mouse) >20,000 (EC50) (human)
SERTTooltip Serotonin transporter >30,000 (Ki) >100,000 (IC50Tooltip half-maximal...
-
Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
-
Norepinephrine transporter (NRIsTooltip
Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter (SRIsTooltip
Serotonin reuptake inhibitors) VMATsTooltip...
-
SSRIs at the
human SERT and rat
sigma receptors Medication SERTTooltip Serotonin transporter σ1 σ2 σ1 / SERT
Citalopram 1.16 292–404
Agonist 5,410 252–348...
