-
Seliciclib (
roscovitine or CYC202) is an
experimental drug
candidate in the
family of
pharmacological cyclin-dependent
kinase (CDK)
inhibitors that preferentially...
- (including
cancer cells), and
released cells rapidly enter mitosis.
Roscovitine can be used to
inhibit the
activity of cyclin-dependent
kinases (CDKs)...
- S, Gianella-Borradori A, et al. (June 2005). "Seliciclib (CYC202, R-
Roscovitine)
induces cell
death in
multiple myeloma cells by
inhibition of RNA polymerase...
- an
orphan drug for
treatment of
chronic lymphocytic leukemia (CLL).
Roscovitine- a pan-CDK
inhibitor against CDK2, CDK7, CDK9. It is
currently in phase...
-
Flavopiridol (alvocidib) 1, 2, 4, 6, 9
Acute Myeloid Leukemia (AML)
Roscovitine (Seliciclib) 2, 7, 9
Pituitary Cushing Disease Cystic Fibrosis, Advanced...
- the
treatment of
breast cancer and AML/MDS.
Seliciclib (CYC202 or R-
roscovitine), a CDK (cyclin
dependent kinase) inhibitor, is in
Phase 2
studies for...
-
sperm injection (ICSI) cycles.
Another of
method is by
using the drug
Roscovitine, this
reduces the
activity of M-phase
promoting factor activity in mice...
- Levy J,
Meskinyte I,
Stankevicius V,
Kaupinis A,
Valius M (June 2015). "
Roscovitine in
cancer and
other diseases".
Annals of
Translational Medicine. 3 (10):...
-
INHIBITION OF CDK5-P25 BY
ROSCOVITINE,
ALOISINE AND INDIRUBIN. 1unh:
STRUCTURAL MECHANISM FOR THE
INHIBITION OF CDK5-P25 BY
ROSCOVITINE,
ALOISINE AND INDIRUBIN...
- 008. PMID 15893728. Wesierska-Gadek J,
Gueorguieva M,
Horky M (2005). "
Roscovitine-induced up-regulation of p53AIP1
protein precedes the
onset of apoptosis...
