-
Resolvins are
specialized pro-resolving
mediators (SPMs)
derived from omega-3
fatty acids,
primarily eicosapentaenoic acid (EPA) and
docosahexaenoic acid...
-
orchestrating the
resolution of inflammation.
Prominent members include the
resolvins and protectins. SPM join the long list of
other physiological agents which...
-
prominently the prostaglandins, thromboxanes, leukotrienes, lipoxins,
resolvins, and eoxins. For each subfamily,
there is the
potential to have at least...
-
dramatically reduce inflammation through conversion within the body to
resolvins, with
beneficial effects for the
cardiovascular system and arthritis....
- but also many
other agents including the
docosanoids resolvin D1,
resolvin D2, and 17R-
resolvin D1 (see
specialized pro-resolving mediators; oligopeptides...
- anti-inflammatory
specialized proresolving mediators, i.e. lipoxins,
resolvins, maresins, and
neuroprotectins Downregulation of pro-inflammatory molecules...
-
cyclooxygenase 2-derived
resolvin E
series metabolites of the
omega 3
fatty acid,
eicosapentaenoic acid;
certain 15-lipoxygenase-derived
resolvin D
series metabolites...
-
eicosapentaenoic acid
which is
metabolized to the
Resolvin E's;
docosahexaenoic acid
which is
metabolized to the
resolvin D's, maresins, and neuroprotectins; and...
-
constitutive signaling activity. At
least 6
members of the D
series of
resolvins (RvDs) viz., RvD1, RvD2m AT-RVD1, RvD3, AT-RvD3, and RvD5,
activate their...
- the aspirin-triggered lipoxins(15-epilipoxin-A4/B4), aspirin-triggered
resolvins, and aspirin-triggered maresins.
These mediators possess potent anti-inflammatory...
