-
topoisomerase II
after the
enzyme induces a
break in DNA,
preventing religation of the
break and
leading to cell death. The
basic structure of anthracyclines...
- This
results in a
variable change of
linking number per
cleavage and
religation event. This
mechanism is
distinct from that of the type IA enzymes, and...
-
until religation occurs. No data
suggest that Topo IB "controls" the
swiveling insofar as that it has a
mechanism in
place that
triggers religation after...
-
residues that
coordinate magnesium ions
involved in DNA
cleavage and DNA
religation. The
structure of the
Toprim fold and DNA-binding core of
yeast topoisomerase...
-
stabilizing the
cleavable complex of
topoisomerase I-DNA,
which inhibits the
religation of single-stranded DNA
breaks generated by
topoisomerase I;
lethal double-stranded...
- ac****ulate, however, this is
normally repaired by TOPIIβ
through its
intrinsic religation ability that
rejoins the
cleaved DNA ends.
Failure of TOPIIβ to religase...
-
bridge which connects the DSB ends together, and is
lastly followed by
religation of the DNA strands. To
initiate whole process, the Ku70/80
protein complex...
-
resulting net
rotation of 180°. The
strand exchange is then
followed by the
religation (Stark et al., 1992).
Recombination between two
directly repeated res...
- backbone, the
backbone can be
treated with
phosphatase to
prevent its
religation. The
Gibson scarless ****embly
method allows the
joining of
multiple BioBricks...
-
different ends are generated. The two
different ends can
prevent the
religation of the
vector without any insert, and it also
allows the
fragment to be...
