-
Rebeccamycin (NSC 655649) is a weak
topoisomerase I
inhibitor isolated from
Nocardia bacteria. It is
structurally similar to staurosporine, but does not...
- has been
isolated from soil in ****an.
Lentzea aerocolonigenes produces rebeccamycin. Parte, A.C. "Lechevalieria". LPSN. "Details: DSM-40034". www.dsmz.de...
- Ni****awa T,
Aldrich CC,
Sherman DH (March 2005). "Molecular
analysis of the
rebeccamycin L-amino acid
oxidase from
Lechevalieria aerocolonigenes ATCC 39243"....
-
formed from a
branch point in this
pathway that also
diverges to form
rebeccamycin. An aryl aryl
coupling thought to be
catalyzed by a
cytochrome P450 enzyme...
- 4'-demethylrebeccamycin + S-adenosyl-L-methionine ⇌ {\displaystyle \rightleftharpoons }
rebeccamycin + S-adenosyl-L-homocysteine Demethylrebeccamycin-D-glucose O-methyltransferase...
- A + β-D-glucose This
enzyme catalyses a step in the
biosynthesis of
rebeccamycin.
Ohuchi T, Ikeda-Araki A, Watanabe-Sakamoto A,
Kojiri K,
Nagashima M...
-
kinase inhibitor. The next
landmark discovery came with the
detection of
rebeccamycin (REB) in a
sample of
Lechevalieria aerocolonigenes,
again in soil, but...
- + 2 NH3 + 2 H2O This
enzyme catalyses a step in the
biosynthesis of
rebeccamycin. Ni****awa T, Grüschow S,
Jayamaha DH, Ni****awa-Harada C,
Sherman DH...
- JA,
Forenza S (March 2002). "Discovery of
antitumor indolocarbazoles:
rebeccamycin, NSC 655649, and fluoroindolocarbazoles".
Current Medicinal Chemistry...
- expression,
leading to
differentiation of stem cells.
Staurosporine Rebeccamycin K252a
Midostaurin Caravatti, Giorgio; Meyer, Thomas; Fredenhagen, Andreas;...
