- of
active Ras-
GTP mutants.
Constitutively active Ras (
RasD) is one
which contains mutations that
prevent GTP hydrolysis, thus
locking Ras in a permanently...
-
attaching (binding) to a
molecule of
GTP. The K-
Ras protein is
turned off (inactivated) when it
converts the
GTP to GDP. When the
protein is
bound to...
-
amplify the
strength of the
original first messenger signal. For example,
RasGTP signals link with the
mitogen activated protein kinase (MAPK)
cascade to...
- Subsequently,
GTP present in the
cytosol binds and HRAS-
GTP dissociates from the GEF,
resulting in HRAS activation. HRAS is in the
Ras family,
which also...
-
triphosphate (
GTP) to form
guanosine diphosphate (GDP). The best-known
members are the
Ras GTPases and
hence they are
sometimes called Ras subfamily GTPases...
-
differ significantly only in the C-terminal 40
amino acids.
These Ras genes have
GTP/GDP
binding and
GTPase activity, and
their normal function may be...
-
example are
RAS effector proteins,
which are all able to bind
RAS.
GTP, but
trigger different cell
pathways upon
doing so - such as the
Ras-Raf-MEK-ERK...
-
domains characteristic of the Raf
kinase family:
conserved region 1 (CR1), a
Ras-
GTP-binding self-regulatory domain,
conserved region 2 (CR2), a serine-rich...
-
GTPases such as RhoA, Rac1, and Rac2. The GAPs that act on
small GTP-binding
proteins of the
Ras superfamily have
conserved structures and use
similar mechanisms...
-
interacts with
Ras proteins to
phosphorylate GDP into
GTP, or from an
inactive state to an
active state to
signal cell proliferation.
RAS genes (e.g., MIM...
