-
formation with
Ran-binding
protein (
RanBP). GTPase-activation
leads to the
conversion of
RanGTP to
RanGDP, thus
closing the
Ran cycle.
Ran can
diffuse freely...
-
exclusive nuclear localization of
RanGEFs,
proteins that
exchange GDP to
GTP on
Ran molecules. Thus,
there is an
elevated RanGTP concentration in the nucleus...
-
nucleus (
RanGTP) or the
cytoplasm (
RanGDP).
Nuclear export roughly reverses the
import process; in the nucleus, the
exportin binds the
cargo and
Ran-
GTP and...
- the cytoplasm.
Whereas importins depend on
RanGTP to
dissociate from
their cargo,
exportins require RanGTP in
order to bind to
their cargo.
Nuclear import...
- cytosolically-bound
RanGTP to
RanGDP. It has the
opposite function of the RCC1, a nuclear-located
protein that
converts RanGDP to
RanGTP. Together,
RanGAP and RCC1...
- for
example during female meiosis in most animals. In this instance, a
Ran GTP gradient is the main
regulator of
spindle microtubule organization and...
-
depletion of
endogenous RanGTP. This
suggests that TPX2 is
downstream of
RanGTP activity, but
whether TPX2 is
directly regulated by
RanGTP still remains to be...
-
susceptibility protein (CAS) is an
exportin which in the
nucleus is
bound to
RanGTP. The Cas
family of
proteins are a
family of
proteins that
induce cellular...
- PMID 12176322. S2CID 15515037.
Moroianu J,
Blobel G, Radu A (September 1997). "
RanGTP-mediated
nuclear export of
karyopherin alpha involves its
interaction with...
- (XPO1/CRM1) and
Ran-
GTP. Rev
recruits this
export machinery via a
nuclear export sequence (NES)
present in Rev. This Rev-RRE-Xpo1/
RanGTP complex is then...
