-
formation with
Ran-binding
protein (
RanBP). GTPase-activation
leads to the
conversion of
RanGTP to
RanGDP, thus
closing the
Ran cycle.
Ran can
diffuse freely...
-
exclusive nuclear localization of
RanGEFs,
proteins that
exchange GDP to
GTP on
Ran molecules. Thus,
there is an
elevated RanGTP concentration in the nucleus...
- cytosolically-bound
RanGTP to
RanGDP. It has the
opposite function of the RCC1, a nuclear-located
protein that
converts RanGDP to
RanGTP. Together,
RanGAP and RCC1...
-
nucleus (
RanGTP) or the
cytoplasm (
RanGDP).
Nuclear export roughly reverses the
import process; in the nucleus, the
exportin binds the
cargo and
Ran-
GTP and...
- the cytoplasm.
Whereas importins depend on
RanGTP to
dissociate from
their cargo,
exportins require RanGTP in
order to bind to
their cargo.
Nuclear import...
- for
example during female meiosis in most animals. In this instance, a
Ran GTP gradient is the main
regulator of
spindle microtubule organization and...
- (June 2005). "Structural
basis for
nuclear import complex dissociation by
RanGTP". Nature. 435 (7042): 693–6. Bibcode:2005Natur.435..693L. doi:10.1038/nature03578...
- Kaláb P,
Pralle A,
Isacoff EY,
Heald R, Weis K (March 2006). "Analysis of a
RanGTP-regulated
gradient in
mitotic somatic cells". Nature. 440 (7084): 697–701...
-
converts RanGDP to
RanGTP in the nucleus,
activating Ran for the
export of proteins. When the
Ran GAP
catalyzes conversion of
RanGTP to
RanGDP in the...
- the
Ran-
GTP to GDP, and this
causes a
conformational change in
Ran,
ultimately reducing its
affinity for importin.
Importin is
released and
Ran-GDP is...
