Definition of Ragulator. Meaning of Ragulator. Synonyms of Ragulator

- The Ragulator-Rag complex is a regulator of lysosomal signalling and trafficking in eukaryotic cells, which plays an important role in regulating cell...
- of the TSC1/TSC2 complex, upstream of mTORC1. mTORC1 interacts at the Ragulator-Rag complex on the surface of the lysosome in response to amino acid levels...
- stimulation. Kagan also identified reactive oxygen species, controlled by the Ragulator-Rag-mTORC1 pathway, as regulators of GSDMD, with oxidation of a specific...
- activation and function. Upon activation by Rheb, mTORC1 localizes to the Ragulator-Rag complex on the lysosome surface where it then becomes active in the...
- binding molecular adaptor activity Cellular component cytoplasm cytosol Ragulator complex lysosomal membrane lysosome Biological process regulation of cell...
- Cellular component endosome membrane late endosome membrane focal adhesion Ragulator complex lysosomal membrane endosome membrane extracellular exosome late...
- ion binding Cellular component integral component of membrane endosome Ragulator complex late endosome lysosome membrane late endosome membrane nucleoplasm...
- activate mTORC1 and Rag7 proteins localize mTORC1 to the lysosome and the Ragulator-Rag complex, allowing RHEB to activate the protein. RHEB acts as an activator...
- Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (April 2010). "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for...
- lysosomal membrane lysosome intracellular membrane-bounded organelle Ragulator complex Biological process regulation of cell size protein localization...