- pro-caspase-1 via its CARD
domain to
activate inflammatory signaling and
pyroptotic cell death. Notably, the PYD of the
adaptor protein ASC has been demonstrated...
-
novel therapeutic opportunities,
namely caspase-1
which controls the
pyroptotic pathway. In this regard,
pyroptosis of CD4 T
cells and
secretion of pro-inflammatory...
- by
inflammatory caspases through both the
canonical and non-canonical
pyroptotic pathways. Caspase-1,
conserved in vertebrates, is
involved in the canonical...
-
pyroptosis exhibit membrane blebbing and
produce protrusions known as
pyroptotic bodies, a
process not
found in necroptosis. Also,
necroptosis works in...
-
inflammasome complex or Caspase-1 activation. A
crucial downstream substrate for
pyroptotic caspases is
Gasdermin D (GSDMD)
Inflammation is a
protective attempt by...
- (2015-09-08). "Cell-to-Cell
Transmission of HIV-1 Is
Required to
Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells". Cell Reports. 12 (10):...
-
novel therapeutic opportunities targeting caspase-1,
which controls the
pyroptotic cell
death pathway. Specifically,
these findings could open the door to...
- PMC 8588876. PMID 33883744. S2CID 233351704.
Jorgensen I, Miao EA (May 2015). "
Pyroptotic cell
death defends against intracellular pathogens".
Immunological Reviews...
- (2015-10-29). "Cleavage of
GSDMD by
inflammatory caspases determines pyroptotic cell death". Nature. 526 (7575): 660–665. Bibcode:2015Natur.526..660S...
- to
provide immune defense by
exposing cytosolic bacteria infecting the
pyroptotic cell to
extracellular immune defenses,
including other immune cells such...
