- or
pseudosubstrate is a
protein that has
similar structure to the
substrate of an enzyme, in
order to make the
enzyme bind to the
pseudosubstrate rather...
-
inhibited by a
pseudosubstrate that
binds to the
kinase like a real
substrate but
lacks the
amino acid to be phosphorylated. When the
pseudosubstrate is removed...
- isoforms, but
functional as a Ca2+
sensor only in the conventional. The
pseudosubstrate region,
which is
present in all
three classes of PKC, is a
small sequence...
- or Thr
residues in substrates. The
autoinhibitory domain features a
pseudosubstrate site,
which binds to the
catalytic domain and
blocks its
ability to...
-
other layers of regulation,
including modulation by the heat
stable pseudosubstrate inhibitor of PKA,
termed PKI.
Below is a list of the
steps involved...
-
contains its own
pseudosubstrate motifs to
occlude substrate binding, the CDK1–cyclin B
complex inhibits separase by
rigidifying pseudosubstrate motifs from...
-
granzyme B. The
reactive loop
centre (RCL) of the PI-9
molecule acts as a
pseudosubstrate and
initially forms a
reversible Michaelis complex. Once the peptide...
-
stably binds and
inhibits the anaphase-promoting complex/cyclosome as a
pseudosubstrate inhibitor".
Genes & Development. 20 (17): 2410–2420. doi:10.1101/gad...
- understood,
although it is
hypothesized that the MCC
binds to APC as a
pseudosubstrate using the KEN-box
motif in BUBR1. At the same time that
mitotic checkpoint...
- the protein's C-Terminal domain, a
region believed to
behave as a
pseudosubstrate, and
inhibits kinase activity. The
Casein kinase 1
epsilon protein...
