- or
pseudosubstrate is a
protein that has
similar structure to the
substrate of an enzyme, in
order to make the
enzyme bind to the
pseudosubstrate rather...
- isoforms, but
functional as a Ca2+
sensor only in the conventional. The
pseudosubstrate region,
which is
present in all
three classes of PKC, is a
small sequence...
-
inhibited by a
pseudosubstrate that
binds to the
kinase like a real
substrate but
lacks the
amino acid to be phosphorylated. When the
pseudosubstrate is removed...
-
other layers of regulation,
including modulation by the heat
stable pseudosubstrate inhibitor of PKA,
termed PKI.
Below is a list of the
steps involved...
- or Thr
residues in substrates. The
autoinhibitory domain features a
pseudosubstrate site,
which binds to the
catalytic domain and
blocks its
ability to...
-
contains its own
pseudosubstrate motifs to
occlude substrate binding, the CDK1–cyclin B
complex inhibits separase by
rigidifying pseudosubstrate motifs from...
-
granzyme B. The
reactive loop
centre (RCL) of the PI-9
molecule acts as a
pseudosubstrate and
initially forms a
reversible Michaelis complex. Once the peptide...
- the protein's C-Terminal domain, a
region believed to
behave as a
pseudosubstrate, and
inhibits kinase activity. The
Casein kinase 1
epsilon protein...
- dsRNA,
dimerization block,
dephosphorylation of
substrate or by a
pseudosubstrate. Some
mechanisms are
still unknown, for instance, in
Lymphocytic choriomeningitis...
-
stabilizing covalent DNA–protein
reaction intermediates or by
creating a
pseudosubstrate,
which traps the
enzyme on DNA.
Camptothecin derivatives, such as irinotecan...
