-
kingdoms of life.
Pseudokinases have both
physiological (signal transduction) and
pathophysiological functions. The
phrase pseudokinase was
first coined...
- CAMKK2
Pseudokinases are pseudoenzymes,
proteins that
resemble enzymes structurally, but lack
catalytic activity. Some of
these pseudokinases that are...
-
Protein kinases can be
classed as
catalytically active (canonical) or as
pseudokinases,
reflecting the
evolutionary loss of one or more of the
catalytic amino...
- known,
conceptually similar to the
kinase and
pseudokinase domain polypeptide structure of the JAK
pseudokinases. A
complete comparative analysis of human...
-
pseudoenzymes in
terms of
cellular signalling functions are
probably the
pseudokinases, the
pseudoproteases and the pseudophosphatases. Recently, the pseudo-deubiquitylases...
- into the
evolution of
divergent nucleotide-binding
mechanisms among pseudokinases revealed by
crystal structures of
human and
mouse MLKL". Biochem. J...
-
Eyers PA, et al. (January 2014). "A
robust methodology to
subclassify pseudokinases based on
their nucleotide-binding properties". The
Biochemical Journal...
- of
signal transduction involves around 560
known protein kinases and
pseudokinases,
encoded by the
human kinome As is the case with GPCRs,
proteins that...
- (August 2023). "Progress on the
Pharmacological Targeting of J****
Pseudokinases".
Journal of
Medicinal Chemistry. 66 (16): 10959–10990. doi:10.1021/acs...
-
changes in the JAK
protein to
facilitate binding of substrate. JH2 is a
pseudokinase domain, a
domain structurally similar to a
tyrosine kinase and essential...
