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Pseudokinases are catalytically-deficient
pseudoenzyme variants of
protein kinases that are
represented in all
kinomes across the
kingdoms of life. Pseudokinases...
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Mixed lineage kinase domain like
pseudokinase (MLKL) is a
protein that in
humans is
encoded by the MLKL gene. This gene
belongs to the
protein kinase superfamily...
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Eyers PA, et al. (January 2014). "A
robust methodology to
subclassify pseudokinases based on
their nucleotide-binding properties". The
Biochemical Journal...
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previously thought to have no
kinase functionality and
accordingly termed a
pseudokinase domain, has
since been
found to be
catalytically active,
albeit at only...
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changes in the JAK
protein to
facilitate binding of substrate. JH2 is a
pseudokinase domain, a
domain structurally similar to a
tyrosine kinase and essential...
- known,
conceptually similar to the
kinase and
pseudokinase domain polypeptide structure of the JAK
pseudokinases. A
complete comparative analysis of human...
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humans is
encoded by the
SELENOO gene. This gene
encodes a selenoprotein,
pseudokinase selenoprotein-O(SelO), that is
localized to the mitochondria. It is the...
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Protein kinases can be
classed as
catalytically active (canonical) or as
pseudokinases,
reflecting the
evolutionary loss of one or more of the
catalytic amino...
-
human protein kinases, and
refers to both
protein kinases and
protein pseudokinases and
their evolution of
protein kinases throughout the eukaryotes. Other...
- CAMKK2
Pseudokinases are pseudoenzymes,
proteins that
resemble enzymes structurally, but lack
catalytic activity. Some of
these pseudokinases that are...
