- in the liver.
Parent non-toxic
chemicals are
generally referred to as
protoxins.
While toxication is
generally undesirable, in
certain cases it is required...
-
Protoxin-II, also
known as ProTx-II, PT-II or β/ω-TRTX-Tp2a, is a
neurotoxin that
inhibits certain voltage-gated
calcium and voltage-gated
sodium channels...
-
Protoxin-I, also
known as ProTx-I, or Beta/omega-theraphotoxin-Tp1a, is a 35-amino-acid
peptide neurotoxin extracted from the
venom of the
tarantula Thrixopelma...
- Cry1Ac
protoxin is a
crystal protein produced by the gram-positive bacterium,
Bacillus thuringiensis (Bt)
during sporulation. Cry1Ac is one of the delta...
- provocation. In 2014,
researchers at Yale
University identified a
toxin called Protoxin-I from the tarantula's
venom that
shows promise as a new
painkiller drug...
-
acute kidney injury. It is not the
myoglobin itself that is
toxic (it is a
protoxin), but the
ferrihemate portion that is
dissociated from
myoglobin in acidic...
-
structure of
proaerolysin has been
determined to 2.8A
resolution and
shows the
protoxin to
adopt a
novel fold.
Images of an
aerolysin oligomer derived from electron...
-
margins 'Violaceum' –
younger shoots and
branches have
bluish color A
protoxin present in the
seeds of Acer negundo, hypoglycin A, has been identified...
-
substances are
bioactivated by CYP3A4 to form
their active compounds, and many
protoxins are
toxicated into
their toxic forms (see
table below for examples). CYP3A4...
-
prodrugs are
converted into
their active metabolites, or the
toxication of
protoxins into
actual toxins. An
enzyme may be
reversibly or
irreversibly bioactivated...
