-
which aggregates into
protofibrils.
Another thrombin-generated enzyme,
factor XIII, then
crosslinks the
fibrin protofibrils at the D
fragment site,...
- of the
humanized version of a
mouse antibody, mAb158, that
recognizes protofibrils and
prevents amyloid beta
deposition in
animal models of Alzheimer's...
- are originated,
which in turn
intertwine in
pairs to form
protofibrils. Four
protofibrils give
place to one
cytokeratin filament. In the cytoplasm, keratin...
- form a protofilament. Two
protofilaments aggregate to form a
protofibril, and four
protofibrils polymerize to form the
intermediate filament (IF). The IF...
-
conformation change of the Aβ
peptide and
increased formation of
toxic Aβ
protofibrils. Non-genetic risk
factors for
early onset sporadic Alzheimer's disease...
- by
thrombin (IIa). New N-terminals link to γA
chains of D
domains and
protofibrils begin to form. #
Fibrinopeptides B (FpB) are cut off by
thrombin a bit...
- (BAN2401), is a
humanized mAb that
selectively targets toxic soluble Aβ
protofibrils, In
phase 3
clinical trials,
Lecanemab showed a 27%
slower cognitive...
-
observed structural pattern is the 9+2
pattern in
which two
central protofibrils are
surrounded by nine
other pairs.
Cellulose inside plants is one of...
- ****ociate head-to-tail into
protofilaments that pair up
laterally into
protofibrils, four of
which wind
together into an
intermediate filament. Part of the...
- 'Arctic' APP
mutation (E693G)
causes Alzheimer's
disease by
enhanced Abeta protofibril formation".
Nature Neuroscience. 4 (9): 887–893. doi:10.1038/nn0901-887...
