- The
prothrombinase enzyme complex consists of
factor Xa (a
serine protease) and
factor Va (a
protein cofactor). The
complex ****embles on
negatively charged...
-
optimized when
factor Xa is
complexed with
activated co-factor V in the
prothrombinase complex.
Factor Xa is
inactivated by
protein Z-dependent
protease inhibitor...
- F2-gene. It is
proteolytically cleaved during the
clotting process by the
prothrombinase enzyme complex to form thrombin.
Thrombin (Factor IIa) (EC 3.4.21.5...
-
factor pathway inhibitor (TFPI). FXa and its co-factor FVa form the
prothrombinase complex,
which activates prothrombin to thrombin.
Thrombin then activates...
- and
cardiac arrest. One of the main
components of the
venom is the
prothrombinase complex pseutarin-C,
which breaks down prothrombin. John White, the...
- coagulation,
uninhibited factor Xa
forms a
prothrombinase complex with
factor Va on
platelet surfaces.
Prothrombinases turn
prothrombins to thrombins. Thrombins...
-
platelet membrane surface.
These phospholipids then bind the
tenase and
prothrombinase complexes, two of the
sites of
interplay between platelets and the coagulation...
- AndexXa.
Rivaroxaban inhibits both free and
bound Factor Xa in the
prothrombinase complex. It is a
selective direct factor Xa
inhibitor with an onset...
- Quinn-Allen, M. A.; Kane, W. H.; Lentz, B. R. (2011). "Modulation of
Prothrombinase ****embly and
Activity by Phosphatidylethanolamine".
Journal of Biological...
- X activators, and
anticoagulant activities (including
inhibitors of
prothrombinase complex formation,
inhibitors of thrombin, phospholipases, and protein...
