-
eukaryotes and is the
primary mediator of
transcriptional responses to
proteotoxic stress with
important roles in non-stress
regulation such as development...
- co-chaperones (proteins that ****ist
protein folding) may
antagonize proteotoxicity during aging and in
protein misfolding-diseases to
maintain proteostasis...
-
protect the
organism from anti****ted
proteotoxic stress.
Cellular stress response pathways detect and
alleviate proteotoxic stress which is
triggered by imbalances...
- and termination,
mechanisms of
cellular adaptation to
genotoxic and
proteotoxic stress, as well as his role in the
discovery of
riboswitches and RNA...
-
cellular stress can
cause protein misfolding and
aggregation leading to
proteotoxicity.
Tumor microenvironment stress leads to
canonical and
noncanonical endoplasmic...
-
shock genes. As a result, the
bacteria would be
unable to cope with
proteotoxic stress,
leading to cell death.[citation needed] PafE
forms a dodecameric...
-
translation (protein synthesis)
allowing lymphoma cells to
escape MYC
induced proteotoxic stress and apoptosis, then later, DDX3Y
mutations restore high level...
- rate of
proteotoxicity over time. However, if
aging is ****ociated with
decline in the
activity of
protective mechanisms against proteotoxicity, the slow...
-
reticulum because of an ac****ulation of
unfolded proteins,
resulting in
proteotoxic impairment of cell function.
Autophagy is
upregulated to
promote survival...
- 00077. PMC 4179678. PMID 25324717.
Sandri M,
Robbins J (June 2014). "
Proteotoxicity: an
underappreciated pathology in
cardiac disease".
Journal of Molecular...
