-
Proteostasis is the
dynamic regulation of a balanced,
functional proteome. The
proteostasis network includes competing and
integrated biological pathways...
- pathogenesis,
although the
trigger for this
aggregation is debated.
Proteostasis disruption and the
dysfunction of cell organelles,
including endosomes...
-
Telomere shortening (or
telomere attrition)
Epigenetic alterations Loss of
proteostasis macroautophagy Antagonistic hallmarks (responses to damage) Deregulated...
- temperatures,
oxidative stress, and
heavy metals. In a
normal cell,
proteostasis (protein homeostasis) must be
maintained because proteins are the main...
- has
investigated the role of the
immune system and
numerous aspects of
proteostasis in the
extraordinary resilience of
naked mole-rats
against many forms...
-
methylation patterns, from
hypomethylation to hypermethylation. loss of
proteostasis (protein
folding and proteolysis)
deregulated nutrient sensing (relating...
- hypergravity, and food restriction. The
example of heat
shock refers to the
proteostasis network. The
addition of a bit of
stress on the cell can lead to activation...
- and
identified lineage-specific
variants affecting DNA
repair genes,
proteostasis,
metabolism regulation and
immune response as key
processes during the...
-
metabolism Mitochondrial diseases Phosphorus metabolism disorders Porphyrias Proteostasis deficiencies Metabolic skin
diseases Wasting syndrome Water-electrolyte...
- (September 2021). "Mitochondrial DNA
variants modulate N-formylmethionine,
proteostasis and risk of late-onset
human diseases".
Nature Medicine. 27 (9): 1564–1575...
